![]() ![]() In 2019 a team of researchers, led by Dr Conrad, identified an enzyme as a novel and strong inhibitor of ferroptosis: ferroptosis suppressor protein-1, short FSP1. Unraveling the long-sought-after vitamin K reducing enzyme FSP1 "Surprisingly, we identified that vitamin K, including phylloquinone (vitamin K1) and menaquinone-4 (vitamin K2), are able to efficiently rescue cells and tissues from undergoing ferroptosis" Dr Mishima explained. To identify these new molecules, a team of researchers led by Dr Eikan Mishima (Tohoku University) and Dr Marcus Conrad (Helmholtz Munich), systematically studied several naturally occurring vitamins, as well as their derivatives. Since ferroptosis prevention is considered a highly promising approach for the therapy of many degenerative diseases, new mechanisms and compounds regulating ferroptosis are extensively being explored. Vitamin K is a potent ferroptosis suppressor The findings suggest that vitamin K treatment might be a new powerful strategy to ameliorate these ferroptosis-related diseases. Recently, ferroptosis has been implicated as a driver of Alzheimer's disease and acute organ injuries among many other diseases. ![]() In addition, the team identified FSP1 as the warfarin-insensitive enzyme reducing vitamin K, the identity of which had been postulated but remained unknown for more than half a century. Ferroptosis is a natural form of cell death that is characterized by extensive lipid peroxidation in cellular membranes. The researchers discovered that the fully reduced form of vitamin K acts as an antioxidant efficiently inhibiting ferroptotic cell death. Aug 4 2022Ī team of researchers at Tohoku University has reported on a novel function of vitamin K, which is generally known for its importance in blood clotting. ![]()
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